In pursuit of drugs for American trypanosomiasis: evaluation of some "standards" in a mouse model.

K E Kinnamon, B T Poon, W L Hanson, V B Waits

Index: Proc. Soc. Exp. Biol. Med. 216(3) , 424-8, (1997)

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Abstract

Forty-nine "standard" compounds known to be useful in the treatment of other diseases were tested for their suppressive activity against the trypomastigotes of Trypanosoma cruzi-infected mice. The most active was the antidepressant protriptyline, which was almost three times as effective as the reference drug, nifurtimox. A major value of the present data is to demonstrate the refractoriness of the T. cruzi parasite against many of the drug standards that have known biological activity.