European Journal of Medicinal Chemistry 2010-03-01

Synthesis of glycoside derivatives of hydroxyanthraquinone with ability to dissolve and inhibit formation of crystals of calcium oxalate. Potential compounds in kidney stone therapy.

Anna Frackowiak, Przemysław Skibiński, Wiesław Gaweł, Ewa Zaczyńska, Anna Czarny, Roman Gancarz

Index: Eur. J. Med. Chem. 45 , 1001-7, (2010)

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Abstract

Synthesis of glycosyl derivatives of hydroxyanthraquinones (6-10) potentially useful for kidney stone therapy is presented. These compounds were analyzed as inhibitors of calcium oxalate crystals formation as well as substances with the ability of dissolving crystalline calcium oxalate. In addition, the effect of the compounds obtained on real kidney stones was analyzed by ex vivo tests. The tests on L929 and A545 cell lines have shown that the compounds obtained were not cytotoxic.Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.

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