Synthesis of 1??Aryl??1H??indazoles via a Ligand??Free Copper??Catalyzed Intramolecular Amination Reaction

…, X Liu, X Wang, Q Cai, K Ding

Index: Gao, Mingshan; Liu, Xiujie; Wang, Xianyang; Cai, Qian; Ding, Ke Chinese Journal of Chemistry, 2011 , vol. 29, # 6 p. 1199 - 1204

Full Text: HTML

Citation Number: 10

Abstract

Abstract A general synthesis of 1-aryl-1-H-indazoles from o-halogenated aryl aldehydes or ketones and aryl hydrazines was described. This protocol included an intermolecular condensation and a ligand-free copper-catalyzed intramolecular Ullmann-type coupling reaction. This method was applied to a wide range of substrates to produce the indazole products in good yields.