Steroids

Synthesis of 15α-hydroxyestrogen 15-N-acetylglucosaminides

…, S Namba, H Kurihara, J Goto, Y Matsuki, T Nambara

Index: Suzuki, Emako; Namba, Susumu; Kurihara, Hiroyuki; Goto, Junichi; Matsuki, Yasuhiko; Nambara, Toshio Steroids, 1995 , vol. 60, # 3 p. 277 - 284

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Citation Number: 10

Abstract

The synthesis of 15-N-acetylglucosaminides of 15α-hydroxyestrone, 15α-hydroxyestradiol, and 15α-hydroxyestriol (estetrol) is described. The latter two were prepared by condensation of 2-acetamido-1α-chloro1, 2-dideoxy-3, 4, 6-trio-O-acetyl-d-glucopyranose with appropriately protected 15α-hydroxyestrogens by the Koenigs-Knorr reaction employing cadmium carbonate as a catalyst. Subsequent removal of protecting groups with ...