Oxidative decarbonylation of β-arylpyruvic acids using sodium perborate

N Morrow, CA Ramsden, BJ Sargent, CD Wallett

Index: Morrow, Nicholas; Ramsden, Christopher A.; Sargent, Bruce J.; Wallett, Christiaan D. Tetrahedron, 1998 , vol. 54, # 33 p. 9603 - 9612

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Citation Number: 9

Abstract

Oxidation of β-aryl-and β-heteroarylpyruvic acids using sodium perborate tetrahydrate (SPB) in aqueous solution at ambient temperature gives the corresponding arylacetic acids in good yield (68–86%). The mild conditions are convenient for the preparation of thermally unstable acids. In particular the method has been applied to the preparation of an unstable 5- nitroimidazol-2-yl ethanoic acid which could not be obtained using other reagents ...