Synthesis, absolute configuration and conformation of the aldose reductase inhibitor sorbinil
…, J Bordner, BW Dominy, MJ Peterson…
Index: Sarges; Bordner; Dominy; Peterson; Whipple Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1716 - 1720
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Citation Number: 53
Abstract
The aldose reductase inhibitor 2, 3-dihydro-6-fluorospiro [4H-l-benzopyran-4, 4 '-imidazo~ dine]-2 ', 5 '-dione was resolved into its enantiomers. Sorbinil, the S isomer, was found to be a better inhibitor of the enzyme in vitro and in vivo than the corresponding R isomer. X-ray ...
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