Hypobetalipoproteinemic agents. 2. Compounds related to 4-(1-adamantyloxy) aniline

D Lednicer, WE Heyd, DE Emmert…

Index: Lednicer; Heyd; Emmert; et al. Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 69 - 77

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Citation Number: 14

Abstract

U'hile the previously used displacement reaction of sodium 1-adamantyl oxide on 4- fluoronitrobenzene was applicable to the preparation of 4-(1-adamanty1oxy) aniline and several related compounds, certain derivatives were not easily accessible by this route. Thus the recently reported ortho alkylation of anilines and the dicyclohexylcarbodiimide- promoted coupling of I-adamantanol with phenols were useful in the preparation of ...