Arylformamidines with antinociceptive properties

…, RE TenBrink, PF VonVoigtlander…

Index: Gall, M.; McCall, J. M.; TenBrink, R. E.; VonVoigtlander, P. F.; Mohrland, J. S. Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1816 - 1820

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Citation Number: 13

Abstract

A series of formamidines structurally related to clonidine were synthesized and investigated as potential nonopiate analgesics. Several of these compounds showed potent analgesic activity (EDw on HC1 writhing< 1.0 mg/kg) with low potential for hypotensive effects. A qualitative description of the structure-activity relationship of this series reveals that the 2, 4- and 2, 6-dimethylphenyl compounds are more potent analgesics than are the ...