Synthesis of 2-and 2, 3-substituted pyrazolo [1, 5-a] pyridines: scope and mechanistic considerations of a domino direct alkynylation and cyclization of N- …

…, A Fortier, D Sustac Roman, AB Charette

Index: Mousseau, James J.; Bull, James A.; Ladd, Carolyn L.; Fortier, Angelique; Sustac Roman, Daniela; Charette, Andre B. Journal of Organic Chemistry, 2011 , vol. 76, # 20 p. 8243 - 8261

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Citation Number: 45

Abstract

Direct functionalization and tandem processes have both received considerable recent interest due to their cost and time efficiency. Herein we report the synthesis of difficult to obtain 2-substituted pyrazolo [1, 5-a] pyridines through a tandem palladium-catalyzed/silver- mediated elimination/direct functionalization/cyclization reaction involving N- benzoyliminopyridinium ylides. As such, these biologically important molecules are ...