Highly effective copper-catalyzed decarboxylative coupling of aryl halides with alkynyl carboxylic acids

X Qu, T Li, P Sun, Y Zhu, H Yang, J Mao

Index: Qu, Xiaoming; Li, Tingyi; Sun, Peng; Zhu, Yan; Yang, Hailong; Mao, Jincheng Organic and Biomolecular Chemistry, 2011 , vol. 9, # 20 p. 6938 - 6942

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Citation Number: 23

Abstract

We have developed a highly effective copper-catalyzed decarboxylative coupling of alkynylcarboxylic acids with various aryl and alkyl halides at 2 mol% loading of copper. This method is simple, economical and practical for the synthesis of disubstituted alkyne compounds.

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