Relationship between metabolism and radioprotective activity of 2-phenylthiazolidine and its m-bromo derivative.

J P Fernandez, Y Robbe, J P Chapat, J L Chanal, M Genin, H Sentenac-Roumanou, M Fatome

Index: J. Med. Chem. 26(9) , 1317-9, (1983)

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Abstract

Molecular biotransformation of 2-phenylthiazolidine (1) and its m-bromo derivative (2) in the mouse is followed by autoradiographic studies and assessed by analysis of urinary metabolites. Cysteamine (4) is one of the metabolites of compounds 1 and 2. Radioprotective activity and efficacy over a period of time of 1, 2, and 4 correlate closely with distribution and metabolism.