Preparation of ketones via the palladium-catalyzed cross-coupling of acid chlorides with trialkylboranes

GW Kabalka, RR Malladi, D Tejedor, S Kelley

Index: Kabalka, George W.; Malladi, Rama R.; Tejedor, David; Kelley, Shane Tetrahedron Letters, 2000 , vol. 41, # 7 p. 999 - 1001

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Citation Number: 47

Abstract

We recently reported the first coupling of trialkylboranes with acid chlorides using a Suzuki–Miyaura coupling sequence to prepare aliphatic and aromatic ketones via the coupling of trialkylboranes with acyl halides (Scheme 1). 6 In an earlier study, Negishi had reported that tetraalkylborates will react with acid chlorides to form ketones in the absence of catalysts. 7 Subsequently, Uemara developed a palladium-catalyzed reaction involving the use of tetraphenylborates with ...