Synthesis and activity of 2-oxoamides containing long chain beta-amino acids.

Violetta Constantinou-Kokotou, Anna Peristeraki, Christoforos G Kokotos, David A Six, Edward A Dennis

Index: J. Pept. Sci. 11(7) , 431-5, (2005)

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Abstract

2-Oxoamides based on long chain beta-amino acids were synthesized. 1-Benzyl substituted long chain amines, needed for such synthesis, were synthesized starting from Boc-phenylalaninol. The oxidative conversion of a phenyl group to a carboxyl group was used as the key transformation synthetic step. The compounds synthesized were studied for their activity against GIVA PLA(2), and were proven to be weak inhibitors.Copyright (c) 2004 European Peptide Society and John Wiley & Sons, Ltd.