Convenient synthesis of wogonin, a flavonoid natural product with extensive pharmacological activity

…, X Cao, X Wang, QL Guo, QD You

Index: Li, Zhi-Yu; Cao, Xin; Wang, Xin; Guo, Qing-Long; You, Qi-Dong Organic Preparations and Procedures International, 2009 , vol. 41, # 4 p. 327 - 330

Full Text: HTML

Citation Number: 5

Abstract

Wogonin (5, 7-dihydroxy-8-methoxyflavone, 5), a flavonoid natural product first isolated from Scutellaria Radix, is well-known for its anti-inflammation, 1 anti-allergy, 2 anti-tumor3 and anti-hepatitis B virus4 properties. Owing to its extensive applications in medical treatment, researchers have developed several synthetic pathways to obtain this important natural product since the early part of the last century. 5, 6 The initial total syntheses of wogonin ...