5-Carboxyfluorescein tagged N-phenylanthranilamide as a tracer reagent for fluorescence polarization: a robust method to screen MAPK pathway allosteric inhibitors.
Z Nooshin Rezvani, R John Mayer, Weng C Chan
Index: Chem. Commun. (Camb.) 46(12) , 2043-5, (2010)
Full Text: HTML
Abstract
Fluorescence polarization using N(alpha)-(fluorescein-5-carbonyl)-N(epsilon)-(N-[2-fluoro-4-iodophenyl]-3,4-difluoroanthraniloyl)lysyl amide is capable of rapidly identifying inhibitor ligands that bind to an allosteric site in MEK1.
Related Compounds
Related Articles:
2015-11-06
[J. Chromatogr. A. 1419 , 116-24, (2015)]
Gold Nanoparticles Inhibit Matrix Metalloproteases without Cytotoxicity.
2015-08-01
[J. Dent. Res. 94 , 1085-91, (2015)]
2015-10-01
[Thromb. Res. 136 , 769-74, (2015)]
Lumican: a new inhibitor of matrix metalloproteinase-14 activity.
2014-11-28
[FEBS Lett. 588(23) , 4319-24, (2014)]
2015-01-01
[Sci. Rep. 5 , 17956, (2015)]