A pharmacokinetic study of paracetamol in Thai beta-thalassemia/HbE patients.

Jeeranut Tankanitlert, ThadA Howard, Anusorn Temsakulphong, Pornpan Sirankapracha, NoppawanPhumala Morales, Yupin Sanvarinda, Pranee Fucharoen, RussellE Ware, Suthat Fucharoen, Udom Chantharaksri

Index: Eur. J. Clin. Pharmacol. 62(9) , 743-8, (2006)

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Abstract

Thalassemia may alter the pharmacokinetics of several drugs in thalassemic patients. Paracetamol is a commonly used analgesic and antipyretic drug which is extensively metabolized in the liver via glucuronidation. The aim of this study was to compare the pharmacokinetics of paracetamol (PCM) and its metabolites [paracetamol glucuronide (PCM-G), paracetamol sulfate (PCM-S), and paracetamol cysteine (PCM-C)] in 16 patients with 16 normal subjects.