Molecules 2012-01-01

Synthesis of N-substituted acridinediones and polyhydroquinoline derivatives in refluxing water.

Jing-Jing Xia, Ke-Hua Zhang

Index: Molecules 17(5) , 5339-45, (2012)

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Abstract

Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in reﬂuxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing good to excellent yields.

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