Synthesis and cytotoxicity of novel hexahydrothienocycloheptapyridazinone derivatives

A Pau, G Murineddu, B Asproni, C Murruzzu, GE Grella…

Index: Pau, Amedeo; Murineddu, Gabriele; Asproni, Battistina; Murruzzu, Caterina; Grella, Giuseppe E.; Pinna, Gerard A.; Curzu, Maria M.; Marchesi, Irene; Bagella, Luigi Molecules, 2009 , vol. 14, # 9 p. 3494 - 3508

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Citation Number: 8

Abstract

Abstract Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted- hexahydrothienocycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system ...