Metal-Free, One-Pot Oxidative Conversion of Aldehydes to Primary Thioamides in Aqueous Media
AK Yadav, VP Srivastava, LDS Yadav
Index: Yadav, Arvind K.; Srivastava, Vishnu P.; Yadav, Lal Dhar S. Synthetic Communications, 2014 , vol. 44, # 3 p. 408 - 416
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Citation Number: 2
Abstract
One-pot tandem reactions of a variety of aldehydes with aqueous ammonia, molecular iodine, and O,O-diethyl dithiophosphoric acid readily afford the corresponding primary thioamides. This is an inexpensive, practical, and metal-free way of accessing various thioamides from aldehydes in aqueous media. The pure products are obtained simply by filtration followed by successive washing with aqueous sodium thiosulfate and water.
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