Synthesis

Regioselective Dealkylation of 2-Alkoxybenzoic Acid and Its Amide Derivatives with Aliphatic Amines

H Nishioka, M Nagasawa, K Yoshida

Index: Nishioka, Hiroyasu; Nagasawa, Masaaki; Yoshida, Kiyoshi Synthesis, 2000 , # 2 p. 243 - 246

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Citation Number: 10

Abstract

Abstract: The methoxy group of o-anisic acid was cleaved with aliphatic amines in aprotic dipolar solvents. This cleavage reaction was especially smooth when piperazine in dimethylacetamide was used. This method was applicable to a variety of dealkylations of o- alkoxybenzoic acid and ist amide derivatives with high regioselectivity. Key words: amides, carboxylic acids, cleavage, ethers, regioselectivity, o-anisic acid

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