Burkholderia cepacia lipase is an excellent enzyme for the enantioselective hydrolysis of β-heteroaryl-β-amino esters

G Tasnádi, E Forró, F Fülöp

Index: Tasnadi, Gabor; Forro, Eniko; Fueloep, Ferenc Tetrahedron Asymmetry, 2009 , vol. 20, # 15 p. 1771 - 1777

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Citation Number: 31

Abstract

The enantioselective (E> 200) lipase PS-catalysed hydrolysis of β-heteroaryl-β-amino esters is described. The reactions were performed with H2O (0.5 equiv) in either diisopropyl ether or tert-butyl methyl ether at 25° C. The resulting β-heteroaryl-substituted β-amino acid enantiomers were formed in high enantiomeric excess (ee⩾ 97%) and in good yield (⩾ 40%).