Pharmeuropa scientific notes 2005-08-01

The control of impurities in amitriptyline hydrochloride using a reversed-phase hybrid stationary phase.

S P Dixon, A Lodi, J H M Miller, G G Skellern

Index: Pharmeur. Sci. Notes 2005(1) , 15-20, (2005)

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Abstract

An isocratic reversed-phase liquid chromatographic method is described using a hybrid column for the control of synthetic impurities potentially found in amitriptyline hydrochloride. The method has been validated and is capable of controlling impurities to 0.1 per cent.

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