Pannexin 1 facilitates arterial relaxation via an endothelium-derived hyperpolarization mechanism

Dina Gaynullina, Valery I. Shestopalov, Yury Panchin, Olga S. Tarasova

Index: FEBS Lett. 589(10) , 1164-70, (2015)

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Abstract

• We studied endothelium-dependent relaxations in control (WT) and Panx1−/− (KO) mice. • The EDH-like component of endothelium-dependent relaxation is impaired in KO mice. • Blockade of purinergic signaling reduces EDH-like component in WT, but not in KO mice.