Synthesis of Rofecoxib,(MK 0966, Vioxx® 4-(4′-Methylsulfonylphenyl)-3-Phenyl-2 (5H)-Furanone), a Selective and Orally Active Inhibitor of Cyclooxygenase-2

M Thérien, JY Gauthier, Y Leblanc, S Léger…

Index: Synthesis, , # 12 p. 1778 - 1779

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Citation Number: 19

Abstract

... Received 26 January 2001 Publication Date: 12 August 2004 (online). ... magnesium mediated carbometallation of phenylpropargyl alcohol, and applied this methodology to synthesize Rofecoxib. ... In conclusion, a highly efficient synthesis of the COX-2 inhibitor Rofecoxib has been ...