Dendritic Glycopolymer as Drug Delivery System for Proteasome Inhibitor Bortezomib in a Calcium Phosphate Bone Cement: First Steps Toward a Local Therapy of Osteolytic Bone Lesions.

Christin Striegler, Matthias Schumacher, Christiane Effenberg, Martin Müller, Anja Seckinger, Reinhard Schnettler, Brigitte Voit, Dirk Hose, Michael Gelinsky, Dietmar Appelhans

Index: Macromol. Biosci. 15 , 1283-95, (2015)

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Abstract

Establishment of drug delivery system (DDS) in bone substitute materials for local treatment of bone defects still requires ambitious solutions for a retarded drug release. We present two novel DDS, a weakly cationic dendritic glycopolymer and a cationic polyelectrolyte complex, composed of dendritic glycopolymer and cellulose sulfate, for the proteasome inhibitor bortezomib. Both DDS are able to induce short-term retarded release of bortezomib from calcium phosphate bone cement in comparison to a burst-release of the drug from bone cement alone. Different release parameters have been evaluated to get a first insight into the release mechanism from bone cements. In addition, biocompatibility of the calcium phosphate cement, modified with the new DDS was investigated using human mesenchymal stromal cells. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.