Palladium-catalyzed cross-coupling reaction of aryl trimethoxysilanes with terminal alkynes

Z Ye, M Liu, B Lin, H Wu, J Ding, J Cheng

Index: Ye, Zhishi; Liu, Miaochang; Lin, Baoda; Wu, Huayue; Ding, Jinchang; Cheng, Jiang Tetrahedron Letters, 2009 , vol. 50, # 5 p. 530 - 532

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Citation Number: 21

Abstract

Alkynes are a recurring functional group in a wide range of natural products and other bioactive compounds, as well as versatile intermediates in synthesis. 1 Since its introduction in 1975, the Sonogashira reaction is one of the most straightforward methods for the preparation of aforementioned compounds. 2 Although an impressive variety of modifications have been reported for this reaction, 3 some drawbacks still remained. For example, alkynes substituted with electron- ...