Effect of piperine on antihyperglycemic activity and pharmacokinetic profile of nateglinide.
V Sama, M Nadipelli, P Yenumula, M R Bommineni, R Mullangi
Index: Arzneimittelforschung 62(8) , 384-8, (2012)
Full Text: HTML
Abstract
Piperine (CAS no: 94-62-2), an alkaloid obtained from Piper nigrum and P. longum is a known inhibitor of various enzymes (CYP isozymes) responsible for biotransformation of drugs. By inhibiting the metabolism of drugs, piperine improves the bioavailability of drugs. In the present study piperine (10 mg/kg) significantly increased the dose-dependent anti-hyperglycemic activity of nateglinide (CAS no: 105816-04-4) as evaluated by glucose challenged and alloxan-induced diabetic models, when it was administered with nateglinide. Nateglinide plasma concentrations were also increased, when administered with piperine. The synergistic anti-hyperglycemic activity of nateglinide when administered with piperine can be attributed to increased plasma concentration of nateglinide. The results of this study demonstrate that piperine could be used as a potential bioenhancer along with nateglinide.© Georg Thieme Verlag KG Stuttgart · New York.
Related Compounds
Related Articles:
2013-11-01
[Pak. J. Pharm. Sci. 26(6) , 1229-35, (2013)]
From evidence assessments to coverage decisions?: the case example of glinides in Germany.
2012-01-01
[Health Policy 104(1) , 27-31, (2012)]
Nateglinide--current and future role in the treatment of patients with type 2 diabetes mellitus.
2005-10-01
[Int. J. Clin. Pract. 59(10) , 1218-28, (2005)]
2012-02-01
[Diabetes Obes. Metab. 14(2) , 187-9, (2012)]
Nateglinide (Starlix): update on a new antidiabetic agent.
2003-01-01
[Int. J. Clin. Pract. 57(6) , 535-41, (2003)]