Mineralocorticoid receptor blockade prevents Western diet-induced diastolic dysfunction in female mice.

Brian Bostick, Javad Habibi, Vincent G DeMarco, Guanghong Jia, Timothy L Domeier, Michelle D Lambert, Annayya R Aroor, Ravi Nistala, Shawn B Bender, Mona Garro, Melvin R Hayden, Lixin Ma, Camila Manrique, James R Sowers

Index: Am. J. Physiol. Heart Circ. Physiol. 308 , H1126-35, (2015)

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Abstract

Overnutrition/obesity predisposes individuals, particularly women, to diastolic dysfunction (DD), an independent predictor of future cardiovascular disease. We examined whether low-dose spironolactone (Sp) prevents DD associated with consumption of a Western Diet (WD) high in fat, fructose, and sucrose. Female C57BL6J mice were fed a WD with or without Sp (1 mg·kg(-1)·day(-1)). After 4 mo on the WD, mice exhibited increased body weight and visceral fat, but similar blood pressures, compared with control diet-fed mice. Sp prevented the development of WD-induced DD, as indicated by decreased isovolumic relaxation time and an improvement in myocardial performance (