Validation of a method for the simultaneous quantification of chloroquine, desethylchloroquine and primaquine in plasma by HPLC-DAD

Lina Zuluaga-Idárraga, Natalia Yepes-Jiménez, Carlos López-Córdoba, Silvia Blair-Trujillo

Index: J. Pharm. Biomed. Anal. 95 , 200-6, (2014)

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Abstract

• Chloroquine, desethyl chloroquine and primaquine level were quantified simultaneously by HPLC-DAD. • The method validation parameters were adequate according international standards. • Sample preparation procedure is easy and inexpensive. • The method was successfully applied to plasma patient samples. • The method is suitable to carry out therapeutic efficacy studies.