Protein tyrosine phosphatase 1B (PTP1B) is involved in the defective erythropoietic function of carbamylated erythropoietin.

María Eugenia Chamorro, Romina Eugenia Maltaneri, Daniela Cecilia Vittori, Alcira Beatriz Nesse

Index: Int. J. Biochem. Cell Biol. 61 , 63-71, (2015)

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Abstract

• Epo induced prolonged phosphorylation of proliferation signals in UT-7 cells. • cEpo induced only transient phosphorylation of proliferative pathways. • PTP1B activity was significantly increased in cultures with cEpo. • PTP1B colocalized with both subunits of the heterodimeric receptor used by cEpo. • Phosphatases are involved in the inability of cEpo to act as an erythroid growth factor.