Acridones circumvent P-glycoprotein-associated multidrug resistance (MDR) in cancer cells

VS Gopinath, P Thimmaiah, KN Thimmaiah

Index: Gopinath, Vadiraj S.; Thimmaiah, Padma; Thimmaiah, Kuntebommanahalli N. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 1 p. 474 - 487

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Citation Number: 22

Abstract

Multidrug resistance (MDR) mediated by overexpression of MDR1 P-glycoprotein (P-gp) is one of the best characterized transporter-mediated barriers to successful chemotherapy in cancer patients. Chemosensitizers are the agents that increase the sensitivity of multidrug- resistant cells to the toxic influence of previously less effective drugs. In an attempt to find such vital chemosensitizers, a series of N10-substituted-2-chloroacridone analogous (1– ...