Changes in Serum Amino Acids in Migraine Patients without and with Aura and their Possible Usefulness in the Study of Migraine Pathogenesis.

Izabela Domitrz, Marek D Koter, Malgorzata Cholojczyk, Wojciech Domitrz, Anna Baranczyk-Kuzma, Anna Kaminska

Index: CNS Neurol. Disord. Drug Targets 14(3) , 345-9, (2015)

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Abstract

Results of several studies suggest that serum amino acids monitoring in migraine might be useful as an objective measurement of the disease status.The aim of the present work was to analyze the profile of aliphatic and aromatic amino acids in blood serum of migraine patients without and with aura between attacks.A total number of 37 migraine patients (26 with migraine without aura and 11 with migraine with aura), mean age 39±12 years, and 40 age-matched healthy subjects as the control group, mean age 38±14 years, were included into the study. The levels of glutamic acid, glutamine, histidine (His), valine (Val), isoleucine, leucine (Leu), phenyloalanine, lysine were evaluated.The level of His was significantly higher in both groups of migraine patients (without and with aura) compared to the control group (F(2,74)=10.17, p=0.00). The levels of Val and Leu were significantly different in migraine without but not with aura, when compared with the control group (F(2,74)=4.70, p=0.01 and F(2,74)=4.39, p=0.02, respectively).We found higher level of His in migraine patients without and with aura and lower level of Val and Leu in patients with migraine without aura.