Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants and Agricultural Wastes 1981-01-01

Biochemical effects of some organophosphorus insecticide on new targets in white rats.

A H El-Sebae, E E Enan, S A Soliman, S El-Fiki, E Khamees

Index: J. Environ. Sci. Health B 16(4) , 475-91, (1981)

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Abstract

The three S-n-propyl phosphates and phosphothioates: RH 218, profenofos and prothiophos were compared with fenitrothion in their potential as inhibitors of rat liver and brain AChE. Fenitrothion was more potent as an inhibitor than the three S-n-propyl derivatives. Incubation of hepatic protein enhanced ChE inhibition in brain in the case of fenitrothion, while it reduced the inhibitory effect of the S-n-propyl derivatives. On the other hand, the four organophosphorus esters caused hypoglycemia in both male and female rats and also reduced their blood urea with different degrees.

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