In vitro antifungal activity of two tissue conditioners combined with nystatin, miconazole and fluconazole against Candida albicans.

Narendra Chopde, Amol Pharande, Mayur N Khade, Yogesh R Khadtare, Sanket S Shah, Abhishek Apratim

Index: J. Contemp. Dent. Pract. 13(5) , 695-8, (2012)

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Abstract

To determine and compare antifungal activity of two tissue conditioners combined with nystatin, miconazole and fluconazole against Candida albicans.Two tissue conditioners Viscogel and GC Soft combined with nystatin, miconazole and fluconazole were tested against Candida albicans using agar core inhibition diameter assay. One-way analysis of variance followed by Tukey's post-hoc test was used to test the intergroup difference. p-value < 0.05 was considered statistically significant.Maximum inhibition was seen in the fluconazole groups followed by miconazole and the least inhibition was seen in case of nystatin group.Tissue conditioners when mixed with antifungal agents showed satisfactory inhibition of Candida albicans.Incorporation of antifungal drugs into tissue conditioners shows good inhibition of C. albicans and can be recommended for clinical use.