Carba??acyclonucleoside antiherpetic agents
J Hannah, RL Tolman, JD Karkas…
Index: Hannah; Tolman; Karkas; Liou; Perry; Field Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 5 p. 1261 - 1271
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Citation Number: 32
Abstract
Abstract Ganciclovir 2 and 2′-carba-ganciclovir 5a are anti-viral agents differing structurally only in the replacement of an oxygen by a methylene group and yet expressing their biological properties along mechanistically independent pathways. Methoxy, hydroxy and fluoro derivatives of 2′-carba-ganciclovir were prepared to examine the effect of re- introducing a binding site close to that in the original oxa side chain. The cyclic phosphate ...
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