Protective effect of curcumin against contrast induced nephropathy in rat kidney: what is happening to oxidative stress, inflammation, autophagy and apoptosis?

M Buyuklu, F Mehmet Kandemir, M Ozkaraca, T Set, E Murat Bakirci, E Topal

Index: Eur. Rev. Med. Pharmacol. Sci. 18(4) , 461-70, (2014)

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Abstract

Currently, the number of imaging and interventional procedures that use contrast agents (CAs) is gradually increasing. Oxidative stress plays a significant role in its pathophysiology. Curcumin (CC) is a natural substance with strong antioxidant efficacy.In total, 24 male Wistar-albino rats were divided into four groups with seven rats in each group.Biochemical measurements showed a significant increase (p < 0.001) in urea, creatinine and malondialdehyde (MDA) but a significant decrease (p < 0.001) in glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) levels in the contrast-induced nephropathy (CIN) group compared with the control group. The immunohistochemical examination revealed a significant increase in autophagic and apoptotic cell death ratios and in the inflammatory signal (p < 0.05). Compared with the CIN group, a significant improvement in these unfavorable parameters was observed with CC therapy.The preventive efficacy of CC against an experimental model of CIN has been demonstrated.