Chemico-Biological Interactions 2013-04-25

Donor substrate specificity of bovine kidney gamma-glutamyltransferase

Anita A. Agblor, P. David Josephy

Index: Chem. Biol. Interact. 203(2) , 480-5, (2013)

Full Text: HTML

Abstract

Highlights • Five aromatic or polycyclic aromatic glutathione conjugates were synthesized. • Enzyme kinetic studies were performed for each conjugate as a γ-glutamyltransferase (GGT) donor substrate. • All conjugates tested were substrates for GGT, with a possible trend towards higher Km values for bulkier substrates. • These results clarify the ability of GGT to act in the biotransformation of aromatic compounds.

Related Compounds

Related Articles:

Inhibition of human γ-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors.

2013-03-15

[Biochem. J. 450(3) , 547-57, (2013)]

Cardiohepatic interactions in heart failure: an overview and clinical implications.

2013-06-18

[J. Am. Coll. Cardiol. 61(24) , 2397-405, (2013)]

Pancreatic complications in pediatric choledochal cysts.

2013-09-01

[J. Pediatr. Surg. 48(9) , 1897-902, (2013)]

Low resolution X-ray structure of γ-glutamyltranspeptidase from Bacillus licheniformis: opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion.

2014-09-01

[Biochim. Biophys. Acta 1844(9) , 1523-9, (2014)]

The undernourished neonatal mouse metabolome reveals evidence of liver and biliary dysfunction, inflammation, and oxidative stress.

2014-03-01

[J. Nutr. 144(3) , 273-81, (2014)]

More Articles...