Acute 5-(2-aminopropyl)benzofuran (5-APB) intoxication and fatality: a case report with postmortem concentrations.
Iain M McIntyre, Ray D Gary, Amber Trochta, Susan Stolberg, Robert Stabley
Index: J. Anal. Toxicol. 39(2) , 156-9, (2015)
Full Text: HTML
Abstract
A 20-year-old man, a college student, became unresponsive in front of his girlfriend. He was known to consume alcohol and take an unknown drug at some point while in attendance at a local music festival earlier in the day/evening. Upon arrival of emergency personnel, he was noted to be asystolic and apneic. Despite aggressive medical intervention by emergency personnel and at a local hospital emergency room, he was pronounced deceased within 1.25 h of initial medical attention. Postmortem blood initially screened positive for methamphetamine by ELISA. An alkaline drug screen detected 5-(2-aminopropyl)benzofuran (5-APB) which was subsequently confirmed and quantified by a specific GC-MS SIM analysis following solid-phase extraction. Concentrations were determined in the peripheral blood (2.5 mg/L), central blood (2.9 mg/L), liver (16 mg/kg), vitreous (1.3 mg/L), urine (23 mg/L) and gastric contents (6 mg). No other common amphetamine-like compound was detected, although 5-(2-aminopropyl)-2,3-dihydrobenzofuran (5-APDB) was presumptively identified in both peripheral blood and urine. Alcohol, the only other drug identified, was confirmed at a concentration of 0.02% (w/v). © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Related Compounds
Related Articles:
Aptamer-based polyvalent ligands for regulated cell attachment on the hydrogel surface.
2015-04-13
[Biomacromolecules 16(4) , 1382-9, (2015)]
Bacteriophage PBC1 and its endolysin as an antimicrobial agent against Bacillus cereus.
2015-04-01
[Appl. Environ. Microbiol. 81(7) , 2274-83, (2015)]
H4 histamine receptors inhibit steroidogenesis and proliferation in Leydig cells.
2014-12-01
[J. Endocrinol. 223(3) , 241-53, (2014)]
2014-12-29
[Small 10(24) , 5126-36, (2014)]
2014-10-01
[Biochim. Biophys. Acta 1851(2) , 152-62, (2015)]