Synthesis

A Large Scale and Concise Synthesis of γ-Linolenic Acid from 4-Chlorobut-2-yn-1-ol

S Durand, JL Parrain, M Santelli

Index: Durand, Sandrine; Parrain, Jean-Luc; Santelli, Maurice Synthesis, 1998 , # 7 p. 1015 - 1018

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Citation Number: 27

Abstract

Abstract: A large scale and concise synthesis of γ-linolenic acid is described. The key step of the synthesis involves a copper salt mediated cross-coupling of two different alkynes and chlorobutynol. Key words: γ-linolenic acid, skipped diyne, terminal alkynes, copper- catalyzed cross-coupling reactions