α-Amino acid derived bisphosphonates. Synthesis and anti-resorftive activity

DM Mizrahi, T Waner, Y Segall

Index: Mizrahi, Dana M.; Waner, Trevor; Segall, Yoffi Phosphorus, Sulfur and Silicon and Related Elements, 2001 , vol. 173, p. 1 - 25

Full Text: HTML

Citation Number: 31

Abstract

Abstract Eleven new bisphosphonates were prepared from naturally-occurring 1-amino acids. The synthesis required special attention to amino and side-chain protections. The novel compounds were tested in TPTX (thyroparathyroidectomized) rats against arotinoid- induced hypercalcemia and were compared to alendronate. Most of the compounds showed moderate to no anti-resorptive activity. Two compounds were more active than clodronate, ...