3'-C-branched 2'-deoxy-5-methyluridines: Synthesis, enzyme inhibition, and antiviral properties

…, EM Kaz'mina, NA Novicov, GV Gurskaya…

Index: Fedorov; Kazmina; Novicov; Gurskaya; Bochkarev; Jasko; Victorova; Kukhanova; Balzarini; De Clercq; Krayevsky Journal of Medicinal Chemistry, 1992 ,  vol. 35,  # 24  p. 4567 - 4575

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Citation Number: 32

Abstract

3'-C-methyl-2'-deoxy-a-~-threo-pentofuranosyl) thymine was converted to a mixture of 3'4 '- methylidene-2 ', 3 '-dideoxy-5-methyluridine and 3 '-C-methyl-2 ', 3 '-dideoxy-2 ', 3'-didehydro- 5-methyluridine, which were separated. The stereoselectivity of the Grignard reagent's attachment to 2-deoxyfuranose 3-ulosides has been ruled by the substitute configuration at C1. Also, the effect of the hydroxyl or OBz group configuration at C3 on the condensation ...