Tetrahedron

Synthesis and applications of chiral bis-THF in asymmetric synthesis

A Alexakis, A Tomassini, S Leconte

Index: Alexakis, Alexandre; Tomassini, Axel; Leconte, Stephane Tetrahedron, 2004 ,  vol. 60,  # 42  p. 9479 - 9484

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Citation Number: 18

Abstract

The synthesis of enantiopure bis-THF is described, starting from d-mannitol. Bis-THF is used as chiral ligand for organolithium reagents in four different reactions. The enantioselectivity provided by this ligand is moderate, and the asymmetric induction is in line with the expected model.