New Regioselective Total Syntheses of Antibiotic Renierol, Renierol Acetate, and Renierol Propionate from the 5-Oxygenated Isoquinoline.

…, H Hayashi, N Hiramatsu, T Choshi, E Sugino…

Index: Kuwabara, Nagako; Hayashi, Hiroyuki; Hiramatsu, Noriko; Choshi, Tominari; Sugino, Eiichi; Hibino, Satoshi Chemical and Pharmaceutical Bulletin, 1999 ,  vol. 47,  # 12  p. 1805 - 1807

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Citation Number: 12

Abstract

New total syntheses of renierol (3), renierol acetate (4), and renierol propionate (5) were completed by the synthesis of 5-oxygenated isoquinoline (6) based on the thermal electrocyclic reaction of the 1-azahexatriene system followed by regioselective oxidations of 5-hydroxyisoquinolines (6).