Functional divergence between closely related Baeyer-Villiger monooxygenases from Aspergillus flavus

FM Ferroni, MS Smit, DJ Opperman

Index: Ferroni; Smit; Opperman Journal of Molecular Catalysis B: Enzymatic, 2014 ,  vol. 107, p. 47 - 54

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Citation Number: 5

Abstract

Abstract Baeyer-Villiger monooxygenases (BVMOs) catalyse the chemo-, regio-and enantioselective oxidation of ketones to esters and lactones. To date, most of the cloned BVMOs available are derived from bacteria, although Baeyer-Villiger oxidations using fungi have frequently been demonstrated. Here we report the cloning and characterization of four BVMOs from the fungus Aspergillus flavus NRRL3357. Phylogenetic analysis shows these ...