A copper-catalyzed method for the facially selective addition of Grignard reagents to cyclopropenes
L Liao, JM Fox
Index: Liao, Lian-An; Fox, Joseph M. Journal of the American Chemical Society, 2002 , vol. 124, # 48 p. 14322 - 14323
Full Text: HTML
Citation Number: 69
Abstract
A Cu-catalyzed method for the addition of Grignard reagents to 1-alkyl-3- hydroxymethylcyclopropenes and their MOM ethers is described. The face of addition is syn relative to the hydroxymethyl and alkoxymethyl groups. Excellent diastereoselectivity is observed for a range of alkyl, alkenyl, and alkynylmagnesium halides. The addition reactions create chiral all-carbon quaternary centers, and the cyclopropylmetals that are ...
Related Articles:
Modulable and Highly Diastereoselective Carbometalations of Cyclopropenes
[Didier, Dorian; Delaye, Pierre-Olivier; Simaan, Marwan; Island, Biana; Eppe, Guillaume; Eijsberg, Hendrik; Kleiner, Amir; Knochel, Paul; Marek, Ilan Chemistry - A European Journal, 2014 , vol. 20, # 4 p. 1038 - 1048]