Synthesis of β-phenylhomotaurine

ES Lipina, RI Bodina, TP Efimova, TA Novikova…

Index: Lipina; Bodina; Efimova; Novikova; Perekalin Pharmaceutical Chemistry Journal, 1999 , vol. 33, # 11 p. 598 - 600

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Citation Number: 4

Abstract

Investigations into the synthesis of sulfoanalogs of ~-aminobutyric acid (GABA) are related to the search for new biologically active compounds. A comparative study of the sedative (calming) effects of GABA and homotaurine showed that the latter compound is more active [I]. As is known, introduction of an aryl substituent at the 13 position with respect to the acid group can significantly modify the biological activity of the compound. This was recently con- ...