Peptidyl N-nitrosoanilines: A novel class of cysteine protease inactivators

Z Guo, J Ramirez, J Li, PG Wang

Index: Guo, Zhengmao; Ramirez, Johnny; Li, Jun; Wang, Peng George Journal of the American Chemical Society, 1998 , vol. 120, # 15 p. 3726 - 3734

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Citation Number: 24

Abstract

A series of peptidyl N-nitrosoanilines were designed, synthesized, and evaluated as inactivators of cysteine protease papain and serine protease chymotrypsin. These new compounds exhibited different inhibitory activities toward the cysteine protease papain in a time-and concentration-dependent manner with second-order rate constants (k inact/KI) ranging over 2 orders of magnitude from 0.604 M-1 s-1 (1) to 100.36 M-1 s-1 (7). No ...