Synthesis and biological evaluation of 99m Tc (CO) 3 (His–CB) as a tumor imaging agent

J Wang, J Yang, X Duan, Y Zhang, W Yang…

Index: Wang, Jianjun; Yang, Jing; Duan, Xiaojiang; Zhang, Yanhua; Yang, Wenjiang; Liu, Yu Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7406 - 7409

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Citation Number: 2

Abstract

The chlorambucil l-histidine conjugate was synthesized and radiolabeled with [99mTc (CO) 3]+ core to form the 99mTc (CO) 3 (His–CB) complex. The radiochemical purity of the complex was over 90%. It had good hydrophilicity and was stable at room temperature. The high initial tumor uptake with certain retention, fast clearance from background, good tumor/non-tumor ratios and satisfactory scintigraphic images highlighted the potential of ...