Tetrahedron

Preparation and properties of some α-aza-amino-acid derivatives, their possible use in peptide synthesis

CJ Gray, JC Ireson, RC Parker

Index: Gray,C.J. et al. Tetrahedron, 1977 , vol. 33, p. 739 - 743

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Citation Number: 29

Abstract

Some derivatives of azaglycine and azaphenylalanine are described. Esters of acetyl-and benzoyl-aza-amino-acids rapidly cyclise to stable oxadiazolones and it is concluded that similar derivatives would be unsuitable for aza-peptide synthesis. t-Butyloxycarbonyl- azaglycine azide was too unreactive for use in peptide synthesis. Benzoyl- azaglycylphenylalanine ethyl ester and acetyl-azaphenylalanylphenylalanine ethyl ester ...