Parallel synthesis of benzoxazoles via microwave-assisted dielectric heating

…, M Katkevics, V Ozola, E Suna, H Ghane, T Regberg…

Index: Pottorf, Richard S.; Chadha, Naresh K.; Katkevics, Martins; Ozola, Vita; Suna, Edgars; Ghane, Hadi; Regberg, Tor; Player, Mark R. Tetrahedron Letters, 2003 , vol. 44, # 1 p. 175 - 178

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Citation Number: 147

Abstract

The parallel synthesis of small focused libraries has become an important strategy for the follow-up of screening hits. The benzoxazole scaffold 1 is found in many biologically active compounds, such as elastase inhibitors 1 and H 2 -antagonists. 2 There are several reports 3., , and for the synthesis of benzoxazoles including one which uses solid-phase support. 4 Although the latter method does allow the parallel synthesis of libraries, product diversity is limited ...